The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions
Identifieur interne : 001278 ( Main/Exploration ); précédent : 001277; suivant : 001279The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions
Auteurs : Nick Butz [Allemagne] ; Stefan A. Müller [Allemagne] ; Karl-Heinz Treutner [Allemagne] ; Michail Anurov [Russie] ; Svetlana Titkova [Russie] ; Alexander P. Oettinger [Russie] ; Volker Schumpelick [Allemagne]Source :
- BMC Surgery [ 1471-2482 ] ; 2007.
Abstract
The formation of adhesions following abdominal surgery is a well known problem. In previous studies we demonstrated the efficacy and safety of intraperitoneally applied phospholipids in order to prevent adhesion formation. This study evaluates the influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions.
In 40 Chinchilla rabbits adhesions were induced by median laparotomy, standardized abrasion of the visceral and parietal peritoneum in defined areas of the ventral abdominal wall and the caecum. The animals were randomly divided into four groups. They received either phospholipids 3.0% or normal saline (NaCl 0,9%) (5 ml/kg body weight). In 50% of the rabbits we simulated intraperitoneal bleeding by administration of blood (1,5 ml/kg body weight). The other half served as control group. Ten days following the operation the animals were sacrificed and adhesion formation was assessed by computer aided planimetry and histopathologic examination.
The median adhesion surface area in the NaCl-group (n = 9) amounted to 68,72 mm2, in the NaCl+Blood-group (n = 10) 147,68 mm2. In the Phospholipid (PhL)-group (n = 9) the median adhesion surface area measured 9,35 mm2, in the PhL+Blood-group (n = 9) 11,95 mm2. The phospholipid groups had a significantly smaller adhesion surface area (p < 0.05).
Again these results confirm the efficacy of phospholipids in the prevention of adhesions in comparison to NaCl (p = 0,04). We also demonstrated the adhesion preventing effect of phospholipids in the presence of intraperitoneal blood.
Url:
DOI: 10.1186/1471-2482-7-14
PubMed: 17651501
PubMed Central: 1945018
Affiliations:
- Allemagne, Russie
- Berlin, District de Cologne, District fédéral central, Rhénanie-du-Nord-Westphalie
- Aix-la-Chapelle, Berlin, Moscou
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000078
- to stream Pmc, to step Curation: 000078
- to stream Pmc, to step Checkpoint: 000174
- to stream Ncbi, to step Merge: 000272
- to stream Ncbi, to step Curation: 000272
- to stream Ncbi, to step Checkpoint: 000272
- to stream Main, to step Merge: 001391
- to stream Main, to step Curation: 001278
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions</title><author><name sortKey="Butz, Nick" sort="Butz, Nick" uniqKey="Butz N" first="Nick" last="Butz">Nick Butz</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Surgery, Medical Faculty Rhenish-Westphalian Technical University, Aachen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Medical Faculty Rhenish-Westphalian Technical University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Muller, Stefan A" sort="Muller, Stefan A" uniqKey="Muller S" first="Stefan A" last="Müller">Stefan A. Müller</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Surgery I, Klinikum Mutterhaus der Borromäerinnen, Trier, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery I, Klinikum Mutterhaus der Borromäerinnen, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Treutner, Karl Heinz" sort="Treutner, Karl Heinz" uniqKey="Treutner K" first="Karl-Heinz" last="Treutner">Karl-Heinz Treutner</name><affiliation wicri:level="3"><nlm:aff id="I3">Abdominal Center, Park-Klinik Weissensee, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Abdominal Center, Park-Klinik Weissensee, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Anurov, Michail" sort="Anurov, Michail" uniqKey="Anurov M" first="Michail" last="Anurov">Michail Anurov</name><affiliation wicri:level="3"><nlm:aff id="I4">Joint Institute for Surgical Research Russian Medical State University, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Joint Institute for Surgical Research Russian Medical State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Titkova, Svetlana" sort="Titkova, Svetlana" uniqKey="Titkova S" first="Svetlana" last="Titkova">Svetlana Titkova</name><affiliation wicri:level="3"><nlm:aff id="I4">Joint Institute for Surgical Research Russian Medical State University, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Joint Institute for Surgical Research Russian Medical State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Oettinger, Alexander P" sort="Oettinger, Alexander P" uniqKey="Oettinger A" first="Alexander P" last="Oettinger">Alexander P. Oettinger</name><affiliation wicri:level="3"><nlm:aff id="I4">Joint Institute for Surgical Research Russian Medical State University, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Joint Institute for Surgical Research Russian Medical State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Schumpelick, Volker" sort="Schumpelick, Volker" uniqKey="Schumpelick V" first="Volker" last="Schumpelick">Volker Schumpelick</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Surgery, Medical Faculty Rhenish-Westphalian Technical University, Aachen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Medical Faculty Rhenish-Westphalian Technical University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17651501</idno><idno type="pmc">1945018</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1945018</idno><idno type="RBID">PMC:1945018</idno><idno type="doi">10.1186/1471-2482-7-14</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000078</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000078</idno><idno type="wicri:Area/Pmc/Curation">000078</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000078</idno><idno type="wicri:Area/Pmc/Checkpoint">000174</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000174</idno><idno type="wicri:Area/Ncbi/Merge">000272</idno><idno type="wicri:Area/Ncbi/Curation">000272</idno><idno type="wicri:Area/Ncbi/Checkpoint">000272</idno><idno type="wicri:Area/Main/Merge">001391</idno><idno type="wicri:Area/Main/Curation">001278</idno><idno type="wicri:Area/Main/Exploration">001278</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions</title><author><name sortKey="Butz, Nick" sort="Butz, Nick" uniqKey="Butz N" first="Nick" last="Butz">Nick Butz</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Surgery, Medical Faculty Rhenish-Westphalian Technical University, Aachen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Medical Faculty Rhenish-Westphalian Technical University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Muller, Stefan A" sort="Muller, Stefan A" uniqKey="Muller S" first="Stefan A" last="Müller">Stefan A. Müller</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Surgery I, Klinikum Mutterhaus der Borromäerinnen, Trier, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery I, Klinikum Mutterhaus der Borromäerinnen, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Treutner, Karl Heinz" sort="Treutner, Karl Heinz" uniqKey="Treutner K" first="Karl-Heinz" last="Treutner">Karl-Heinz Treutner</name><affiliation wicri:level="3"><nlm:aff id="I3">Abdominal Center, Park-Klinik Weissensee, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Abdominal Center, Park-Klinik Weissensee, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Anurov, Michail" sort="Anurov, Michail" uniqKey="Anurov M" first="Michail" last="Anurov">Michail Anurov</name><affiliation wicri:level="3"><nlm:aff id="I4">Joint Institute for Surgical Research Russian Medical State University, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Joint Institute for Surgical Research Russian Medical State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Titkova, Svetlana" sort="Titkova, Svetlana" uniqKey="Titkova S" first="Svetlana" last="Titkova">Svetlana Titkova</name><affiliation wicri:level="3"><nlm:aff id="I4">Joint Institute for Surgical Research Russian Medical State University, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Joint Institute for Surgical Research Russian Medical State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Oettinger, Alexander P" sort="Oettinger, Alexander P" uniqKey="Oettinger A" first="Alexander P" last="Oettinger">Alexander P. Oettinger</name><affiliation wicri:level="3"><nlm:aff id="I4">Joint Institute for Surgical Research Russian Medical State University, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Joint Institute for Surgical Research Russian Medical State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Schumpelick, Volker" sort="Schumpelick, Volker" uniqKey="Schumpelick V" first="Volker" last="Schumpelick">Volker Schumpelick</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Surgery, Medical Faculty Rhenish-Westphalian Technical University, Aachen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Medical Faculty Rhenish-Westphalian Technical University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author></analytic><series><title level="j">BMC Surgery</title><idno type="eISSN">1471-2482</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The formation of adhesions following abdominal surgery is a well known problem. In previous studies we demonstrated the efficacy and safety of intraperitoneally applied phospholipids in order to prevent adhesion formation. This study evaluates the influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions.</p></sec><sec sec-type="methods"><title>Methods</title><p>In 40 Chinchilla rabbits adhesions were induced by median laparotomy, standardized abrasion of the visceral and parietal peritoneum in defined areas of the ventral abdominal wall and the caecum. The animals were randomly divided into four groups. They received either phospholipids 3.0% or normal saline (NaCl 0,9%) (5 ml/kg body weight). In 50% of the rabbits we simulated intraperitoneal bleeding by administration of blood (1,5 ml/kg body weight). The other half served as control group. Ten days following the operation the animals were sacrificed and adhesion formation was assessed by computer aided planimetry and histopathologic examination.</p></sec><sec><title>Results</title><p>The median adhesion surface area in the NaCl-group (n = 9) amounted to 68,72 mm<sup>2</sup>, in the NaCl+Blood-group (n = 10) 147,68 mm<sup>2</sup>. In the Phospholipid (PhL)-group (n = 9) the median adhesion surface area measured 9,35 mm<sup>2</sup>, in the PhL+Blood-group (n = 9) 11,95 mm<sup>2</sup>. The phospholipid groups had a significantly smaller adhesion surface area (p < 0.05).</p></sec><sec><title>Conclusion</title><p>Again these results confirm the efficacy of phospholipids in the prevention of adhesions in comparison to NaCl (p = 0,04). We also demonstrated the adhesion preventing effect of phospholipids in the presence of intraperitoneal blood.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Russie</li></country><region><li>Berlin</li><li>District de Cologne</li><li>District fédéral central</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Aix-la-Chapelle</li><li>Berlin</li><li>Moscou</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Butz, Nick" sort="Butz, Nick" uniqKey="Butz N" first="Nick" last="Butz">Nick Butz</name></region><name sortKey="Muller, Stefan A" sort="Muller, Stefan A" uniqKey="Muller S" first="Stefan A" last="Müller">Stefan A. Müller</name><name sortKey="Schumpelick, Volker" sort="Schumpelick, Volker" uniqKey="Schumpelick V" first="Volker" last="Schumpelick">Volker Schumpelick</name><name sortKey="Treutner, Karl Heinz" sort="Treutner, Karl Heinz" uniqKey="Treutner K" first="Karl-Heinz" last="Treutner">Karl-Heinz Treutner</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Anurov, Michail" sort="Anurov, Michail" uniqKey="Anurov M" first="Michail" last="Anurov">Michail Anurov</name></region><name sortKey="Oettinger, Alexander P" sort="Oettinger, Alexander P" uniqKey="Oettinger A" first="Alexander P" last="Oettinger">Alexander P. Oettinger</name><name sortKey="Titkova, Svetlana" sort="Titkova, Svetlana" uniqKey="Titkova S" first="Svetlana" last="Titkova">Svetlana Titkova</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001278 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001278 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:1945018
|texte= The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:17651501" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a UnivTrevesV1
| This area was generated with Dilib version V0.6.31. |  |